1. Acute pain
Studies involving cannabinoids with the treatment of acute pain clinically in laboratory animals. It was found that it can help reduce acute pain.8 THC was almost more effective in reducing pain than morphine 10×1, where THC transmits signals to the delta and kappa opioid-receptors but increases the incidence of the side effects of opioids were also higher1, similar to those of the Bakshi C et al.9 study. The THC-treated group of animals had a 3.6-fold reduction in their need for morphine compared to the control group.
But a systematic review of 8,10 human studies found that cannabinoids do not affect on acute analgesia compared with placebo in the induction trial. Acute pain in healthy people It was found that the pain reduction effectiveness depended on the amount of THC. Received in the lower dose group. It can be effective in reducing pain. But at the same time, if given in high doses. The result was more pain than usual.8 In addition, studies on synthetic cannabinoids (dronabinol and nabilone) are used to relieve pain after surgery. Both substances were found not to affect reducing pain after surgery6.
2. Chronic Pain
Animal studies have shown that endocannabinoids, THC, CBD kaufen, nabilone, and cannabinoids some synthetic have anti-inflammatory effects and pain relief in chronic pain 8. in the review of educational literature RCTs6 model Of the 29 total, 22 studies found that cannabis or cannabis extracts slightly reduced pain. In non-cancer pain without causing additional side effects, it is effective in treating pain from multiple sclerosis and spasticity. It also provides moderate pain relief in neuropathic and cancer-related conditions.
Chronic Noncancer Pain has consistent evidence of CBD kaufen effectiveness. (using pumping/vaping, nabiximols, dronabinol) for the treatment of chronic non-cancer pain, especially in the case of treatment. The traditional method has failed.8 Nabiximols is effective at reducing pain at rest and in motion and improving Improved sleep quality.
A review of the literature by Stockings E et al.11 agrees that marijuana is unlikely to be an effective drug high efficiency for chronic pain other than cancer pain. Chronic Neuropathic Pain Häuser W et al12 reviewed the literature. found that cannabis or extracts Cannabis-induced pain reduction ≥ 30 (NNT = 6, NNH = 25) with poor analgesic effect with side effects high. The study by Allan GM et al.10 conducted a four-week study and follow-up of patients found that in for neuropathic pain, the cannabinoids group experienced a 38 percent reduction in pain, while the control group. Pain level was reduced by 30% (NNT = 14). The Canadian Pain Society6.
Therefore, it is recommended to use CBD kaufen or its extracts. Marijuana is the third option for chronic neuropathic pain, with serotonin reuptake inhibitors. (SSRIs), methadone and topical lidocaine first, but must be used with caution.
Cancer Pain and Palliative (end of life) cancer pain
The clinical evidence for using cannabinoids (dronabinol, nabiximols) in the treatment of pain is quite strong. LIMIT8,12 Based on a literature review by Häuser W et al.12, cannabinoids cause pain levels a decrease of more than 30 percent, which was only slightly better than the experimental group, a study by Allan GM et al.10 A four-week study and follow-up of patients showed a 30 percent reduction in pain levels, while the control group pain level decreased by 23% (NNT approximately = 15). It was also found that pain value scale (0-10) in the chronic pain group. In the cannabinoids group, the mean pain score was six, and the pain scale was reduced. 1.2 to 1.8, while the mean pain control group was six, the pain score decreased by 0.8.